The H1N1 Virus Challenge in Mice

Applicant:Sanshin Nutrition Technology Co., Ltd. (hereinafter called S.S. Nutrition)
Entrusted Institutions:Development Center of Biotechnology (hereinafter called DCB)
Principal Investigator:Prof. Gu-Jiun Lin in National Defense Medical Center
Sample:PRP from S.S. Nutrition
Group:In Yeast group, mice are treated with PRP after the virus challenge.
The control group is normally supplied with water and feed.


1. Determination of influenza A virus TCID50 titer from mouse lung tissues.
The H1N1 virus titer from PRP group is 8.89 x 104 TCID50/ml.
In comparison, the virus titer from control group is 8.89 x 105 TCID50/ml.
After treatment with PRP, the virus titer is decreasing by ten times.

2. The Histology of Lungs in Mice after Influenza Virus Challenge.
When the influenza virus infected lungs, leukocytes would enter the lung to block the virus attack. Consequently, we observed leukocyte-endothelial cell interactions in lungs with histochemical stain with frozen section, to evaluate the effect of yeast for preventing virus from attacking lungs. From the lung of histology, the amount of leukocytes in PRP group is under control. This result indicated that PRP can decrease the rate of H1N1 virus attacking lung tissues.

3. Comparison of the amount of serum H1N1 virus between PRP group and control group.
In the PRP group, the cure rate for H1N1 is 67%. However, in the control group, the cure rate is zero.
Via the virus detection in the serum, feeding mice with PRP could assist immune system in killing the H1N1 virus, which makes a difference between two groups.
ps:The cure rate =(the number of virus-negative mice)/(the number of mice each group) x 100%


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