【Science you and me – Unlimited potential innate immune proteins】

The PGRP ( Tag7 ) protein activates the lymphoid immune cells of the organism to kill infected cells.
[Top] Activated lymphoid immune cells kill infected cells (infSC-1), but activated lymphoid immune cells do not pose a high risk to normal healthy cells.
[Bottom] Lymphatic immune cells activated by Tag7 protein are natural killer NK and CD8+ T cells.
In addition to its antibacterial effect, PGRP ( Tag7 ) protein also helps the body’s lymphoid immune cells to kill virus-infected cells.
If we can successfully use PGRP in the future, it is believed that it will have a significant positive effect on our medicine.

Tag7

[Science you and me – Everlasting innate immune proteins]

Innate immune proteins are antibacterial substances which have existed for millions of years. Their action sites are mainly directed to essential fragments of prokaryotes, so it’s difficult to develop drug-resistant strains.

PGRP is an innate immune protein that binds to peptidoglycan on the bacterial membrane, causing changes in oxidation, thiol or metal ions.

PGRP accelerates the TCA cycle and increases the formation of hydrogen peroxide (H2O2) and hydroxyl radicals (HO·).
PGRP may also cause the consumption of more than 90% of the thiol groups in the cell, which destroys the redox balance of the cells.
The third method of PGRP increases intracellular free Zn2+ and Cu+, which inactivates the enzyme or accelerates the consumption of thiol groups.
In contrast, antibiotics can only produce antibacterial effects in a single location; PGRP can use multiple pathways to inhibit bacteria, but PGRP research is not yet complete and there is currently no commercial PGRP for medical use in the future. If you can use PGRP in a large number of successful ways, it is believed that it will have a significant positive effect on our medicine.
Full paper : Dziarski, Roman, and Dipika Gupta. “How innate immunity proteins kill bacteria and why they are not prone to resistance." Current genetics 64.1 (2018): 125-129.

PGRP-S抗菌效果

 

 

The H1N1 Virus Challenge in Mice

Applicant:Sanshin Nutrition Technology Co., Ltd. (hereinafter called S.S. Nutrition)
Entrusted Institutions:Development Center of Biotechnology (hereinafter called DCB)
Principal Investigator:Prof. Gu-Jiun Lin in National Defense Medical Center
Sample:PRP from S.S. Nutrition
Group:In Yeast group, mice are treated with PRP after the virus challenge.
The control group is normally supplied with water and feed.

Result:

1. Determination of influenza A virus TCID50 titer from mouse lung tissues. 繼續閱讀「The H1N1 Virus Challenge in Mice」